Pharmaceutical industry is an important industry related to people's physical and mental health, including pharmaceuticals, medical machinery, sanitary materials and many other fields, and occupies an important position in the national economy. Titanium is widely used in the pharmaceutical industry due to its non-toxicity, harmlessness and good compatibility with the human body.
In pharmaceutical production, pharmaceutical equipment is easily damaged by corrosion due to the fact that the production of drugs is inseparable from acids, alkalis and salts. The use of steel equipment not only can not solve the problem of serious corrosion of equipment, but also cause a lot of human, material and financial losses, affecting normal production. The use of titanium equipment is a good solution to this problem.
In the production of several major commonly used drugs, the use of titanium equipment has good corrosion resistance, and has gained considerable economic benefits.
- Vitamin B1 production
China's production of vitamin B1 with hydrogen chloride conversion method, the finished product using cyclone drying, two cyclone separation. The medium is thiamine hydrochloride, PH value of 2.5, temperature 110 for ℃, very corrosive. The original drying device is made of stainless steel, more than a year of use on the inner wall of corrosion perforation, and serious contamination of drugs.
The use of titanium spiral feeder, cyclone separator, vortex body, hopper and discharge pipe and exhaust box titanium lining, vitamin B1 production pass rate from the highest 95% to 100%, and the equipment used for more than 7 years have not seen corrosion, 3 months to recover the cost of titanium.
- Vitamin C production
Vitamin C is based on sorbitol as raw material, fermented into sorbose with black vinegar bacteria, and then fermented with Pseudomonas aeruginosa to produce a low concentration of colognes acid, concentrated and converted to finished products by hydrogen chloride.
Titanium is very resistant to corrosion in high temperature colognes. In the production process of this product, the use of titanium tube heat exchanger, titanium DHC a 500 butterfly plate sinking automatic slag centrifuge, TC4 casting impeller, the use of many years have not found corrosion.
- Antimicrobial production
Chloramphenicol (an antibiotic) chemical synthesis of the main raw material is dichloroacetic acid methyl, containing about 2% of chlorinated alkenes, trichloroethylene, which refinement process, if the use of steel equipment, prone to serious corrosion, and changed to titanium equipment so far intact.
- Production of anaesthetics
Local anaesthesia using procaine hydrochloride, the production of p-nitrotoluene as raw material, in the oxidation of p-nitrobenzoic acid, acetic acid washing, mother liquor recycling of the entire production process there is a strong corrosive, so the production equipment using titanium-steel composite plate inner tube, titanium bubble tube, glacial acetic acid circulating condenser as well as vapour-liquid separator, so as to solve the corrosion problem.
- Production of anthelmintic and other medicines
Roundworm net (tetraimidazole) is a highly effective intestinal nematode anthelmintic, the original use of stainless steel equipment in the production of this product, due to corrosion caused by product contamination, changed to titanium for the feed pipe, pump inlet pipe to successfully solve the corrosion problem.
Nitrochlorophenol is a special veterinary drug for the treatment of liver flake schistosomiasis in cattle and sheep, which is produced with sulphuric acid, nitric acid, glacial acetic acid and chlorine-containing solution. The use of titanium pin chemical tank agitator, so far running normally. In addition, in the production of pharmaceuticals commonly used in activated carbon decolourisation, stainless steel suction filter to titanium suction filter, the use of 9 years is still intact.
Abroad in the production of brominated amino acids, bromination, separation, salting out, extraction, evaporation processes are used in titanium reactors. China's quinoline derivatives with the production of malaria drugs, exposure to chlorine ions anti-schistosomiasis drugs, contraceptives, rheumatism, etc. are also necessary to use titanium equipment. Others, such as penicillin esterification kettle, saccharification tank, chloramphenicol film evaporator, anandamide reactor, mithril filter, dimethyl sulphate cooler, liquid filter, etc., have the feasibility and necessity of titanium manufacturing.
